{ "meta": { "data_length": 1, "message": "Proposition id prop:vtxr:879 retrieved successfully", "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A879", "status": "success", "status_code": 200, "timestamp_elapsed": 0.001845, "timestamp_received": "2026-09-25T00:12:28.002378+00:00Z", "timestamp_returned": "2026-09-25T00:12:28.004223+00:00Z", "trace_id": "3f534939-6e3d-41dd-b8d3-fc4c52aedcc0" }, "service": { "github": "https://github.com/vanallenlab/moalmanac-db", "name": "Molecular Oncology Almanac", "license": "GPL-2.0", "release": "draft", "url": "https://dev.moalmanac.org", "last_updated": "2026-08-02" }, "data": [ { "id": "prop:vtxr:879", "type": "VariantTherapeuticResponseProposition", "predicate": "predictsSensitivityTo", "subjectVariant": { "type": "CategoricalVariant", "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. 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"C562", "name": "Idarubicin", "system": "https://evsexplore.semantics.cancer.gov", "systemVersion": "25.01d", "iris": [ "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C562" ] } }, { "id": "tx:ncit:C68936", "conceptType": "Therapy", "name": "Quizartinib", "mappings": [ { "relation": "relatedMatch", "coding": { "id": "coding:rxcui:2643048", "code": "2643048", "name": "quizartinib", "system": "RxNorm", "systemVersion": "02-Mar-2026", "iris": [ "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2643048" ] } }, { "relation": "relatedMatch", "coding": { "id": "coding:omop:746225", "code": "746225", "name": "quizartinib", "system": "OMOP", "systemVersion": "v20260227", "iris": [ "https://athena.ohdsi.org/search-terms/terms/746225" ] } } ], "extensions": [ { "name": "therapy_strategy", "value": [ "FLT3 inhibition" ], "description": "Associated therapeutic strategy or mechanism of action of the therapy." }, { "name": "therapy_type", "value": "Targeted therapy", 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subdomain 1 (Exons 14-15).", "digest": "53HN2VFdgurjdPcQYBRwyfNMHcwRzdID", "sequenceReference": { "id": "ga4gh:SQ.0dtDG7QKyvW7BntvQVpLS83mYRA58LKH", "type": "SequenceReference", "name": "NP_004110.2", "aliases": [ "ensembl:ENSP00000241453.7", "ga4gh:SQ.0dtDG7QKyvW7BntvQVpLS83mYRA58LKH", "refseq:NP_004110.2" ], "description": "The protein product of the MANE Select coding transcript for FLT3 (refseq:NM_004119.3), corresponding to the Refseq protein accession NP_004110.2.", "moleculeType": "protein", "refgetAccession": "SQ.0dtDG7QKyvW7BntvQVpLS83mYRA58LKH", "residueAlphabet": "aa" }, "start": 568, "end": 648, "sequence": null }, "relations": [], "matchCharacteristic": { "primaryCoding": { "code": "is_within", "system": "ga4gh-gks-term:location-match" } } }, { "type": "FeatureContextConstraint", "featureContext": { "id": "gene:hgnc:3765", "conceptType": "Gene", "name": "FLT3", "primaryCoding": { "id": "coding:hgnc:3765", "code": "HGNC:3765", "system": "https://genenames.org", "iris": [ 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null }, { "name": "cdna_change", "value": null }, { "name": "protein_change", "value": null }, { "name": "variant_annotation", "value": "Internal Tandem Duplication (ITD)" }, { "name": "exon", "value": null }, { "name": "rsid", "value": null }, { "name": "hgvsg", "value": null }, { "name": "hgvsc", "value": null }, { "name": "requires_oncogenic", "value": true } ] } } ], "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic." } ] } ] }