{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:927 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A927",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001736,
    "timestamp_received": "2026-09-25T05:26:56.672213+00:00Z",
    "timestamp_returned": "2026-09-25T05:26:56.673949+00:00Z",
    "trace_id": "56dda0f8-62c9-4744-98ed-a904dca69775"
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    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
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      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
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        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:ncit:C4337",
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        "name": "Mantle Cell Lymphoma",
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              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": true,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
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          "name": "Mantle Cell Lymphoma",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
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          ]
        }
      },
      "objectTherapeutic": {
        "id": "tx:ncit:C81934",
        "conceptType": "Therapy",
        "name": "Ibrutinib",
        "mappings": [
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            "relation": "relatedMatch",
            "coding": {
              "id": "coding:rxcui:1442981",
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              "name": "ibrutinib",
              "system": "RxNorm",
              "systemVersion": "02-Mar-2026",
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              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:omop:44507848",
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              "name": "ibrutinib",
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              ]
            }
          },
          {
            "relation": "relatedMatch",
            "coding": {
              "id": "coding:sctid:710228002",
              "code": "710228002",
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              "systemVersion": "2025-03-01",
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              ]
            }
          },
          {
            "relation": "relatedMatch",
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              "id": "coding:omop:46271948",
              "code": "46271948",
              "name": "Ibrutinib",
              "system": "OMOP",
              "systemVersion": "v20260227",
              "iris": [
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              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "therapy_strategy",
            "value": [
              "BTK inhibition"
            ],
            "description": "Associated therapeutic strategy or mechanism of action of the therapy."
          },
          {
            "name": "therapy_type",
            "value": "Targeted therapy",
            "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
          }
        ],
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          "code": "C81934",
          "name": "Ibrutinib",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "25.01d",
          "iris": [
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          ]
        }
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:183",
              "present": true,
              "subject": {
                "id": "bmkr:183",
                "type": "CategoricalVariant",
                "name": "t(11;14)",
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                    "type": "DefiningLocationConstraint",
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                      "type": "SequenceLocation",
                      "name": null,
                      "aliases": [],
                      "description": "GRCh38 chromosome 11 (NC_000011.10), in its entirety.",
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                        "type": "SequenceReference",
                        "name": "NC_000011.10",
                        "aliases": [
                          "ensembl:11",
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                        "moleculeType": "genomic",
                        "refgetAccession": "SQ.2NkFm8HK88MqeNkCgj78KidCAXgnsfV1",
                        "residueAlphabet": "na"
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                      "primaryCoding": {
                        "code": "is_within",
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                    }
                  },
                  {
                    "type": "DefiningLocationConstraint",
                    "location": {
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                      "type": "SequenceLocation",
                      "name": null,
                      "aliases": [],
                      "description": "GRCh38 chromosome 14 (NC_000014.9), in its entirety.",
                      "digest": "Qtjsk-OhOGoPODsXUNw-Ap2h5qp-YRB7",
                      "sequenceReference": {
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                        "type": "SequenceReference",
                        "name": "NC_000014.9",
                        "aliases": [
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                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Translocation"
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                ]
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            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}