{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:929 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A929",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001818,
    "timestamp_received": "2026-09-25T04:53:14.271376+00:00Z",
    "timestamp_returned": "2026-09-25T04:53:14.273194+00:00Z",
    "trace_id": "96e7d78f-b31c-49ee-8ced-328eedc0666f"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
    {
      "id": "prop:vtxr:929",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:oncotree:FL",
        "conceptType": "Disease",
        "name": "Follicular Lymphoma",
        "mappings": [],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": false,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
        "primaryCoding": {
          "id": "coding:oncotree:FL",
          "code": "FL",
          "name": "Follicular Lymphoma",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=FL"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "txgrp:202",
        "membershipOperator": "AND",
        "therapies": [
          {
            "id": "tx:ncit:C73261",
            "conceptType": "Therapy",
            "name": "Bendamustine",
            "mappings": [
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:rxcui:134547",
                  "code": "134547",
                  "name": "bendamustine",
                  "system": "RxNorm",
                  "systemVersion": "02-Mar-2026",
                  "iris": [
                    "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=134547"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:19015523",
                  "code": "19015523",
                  "name": "bendamustine",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/19015523"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:sctid:428012008",
                  "code": "428012008",
                  "name": "Bendamustine",
                  "system": "SNOMED",
                  "systemVersion": "2025-03-01",
                  "iris": [
                    "https://browser.ihtsdotools.org/?perspective=full&conceptId1=428012008&edition=MAIN/2025-03-01&release=&languages=en"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:4175860",
                  "code": "4175860",
                  "name": "Bendamustine",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/4175860"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
                  "Alkylating chemotherapy"
                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Chemotherapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C73261",
              "code": "C73261",
              "name": "Bendamustine",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "25.01d",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C73261"
              ]
            }
          },
          {
            "id": "tx:ncit:C70741",
            "conceptType": "Therapy",
            "name": "Obinutuzumab",
            "mappings": [
              {
                "relation": "exactMatch",
                "coding": {
                  "id": "coding:rxcui:974779",
                  "code": "974779",
                  "name": "obinutuzumab",
                  "system": "RxNorm",
                  "systemVersion": "02-Mar-2026",
                  "iris": [
                    "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=974779"
                  ]
                }
              },
              {
                "relation": "exactMatch",
                "coding": {
                  "id": "coding:omop:44507676",
                  "code": "44507676",
                  "name": "obinutuzumab",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/44507676"
                  ]
                }
              },
              {
                "relation": "exactMatch",
                "coding": {
                  "id": "coding:sctid:710287009",
                  "code": "710287009",
                  "name": "Obinutuzumab",
                  "system": "SNOMED",
                  "systemVersion": "2025-03-01",
                  "iris": [
                    "https://browser.ihtsdotools.org/?perspective=full&conceptId1=710287009&edition=MAIN/2025-03-01&release=&languages=en"
                  ]
                }
              },
              {
                "relation": "exactMatch",
                "coding": {
                  "id": "coding:omop:46271994",
                  "code": "46271994",
                  "name": "Obinutuzumab",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/46271994"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
                  "CD20 inhibition"
                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Targeted therapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C70741",
              "code": "C70741",
              "name": "Obinutuzumab",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "25.01d",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C70741"
              ]
            }
          }
        ]
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:54",
              "present": true,
              "subject": {
                "id": "bmkr:54",
                "type": "CategoricalVariant",
                "name": "CD20 +",
                "constraints": [],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Protein expression"
                  },
                  {
                    "name": "marker",
                    "value": "CD20"
                  },
                  {
                    "name": "unit",
                    "value": "status"
                  },
                  {
                    "name": "equality",
                    "value": "="
                  },
                  {
                    "name": "value",
                    "value": "Positive"
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}