{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:935 retrieved successfully",
    "request_url": "http://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A935",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.00194,
    "timestamp_received": "2026-09-25T04:34:28.750628+00:00Z",
    "timestamp_returned": "2026-09-25T04:34:28.752568+00:00Z",
    "trace_id": "2d9dc9b7-299e-404d-a3b7-b37b7d474b2b"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://dev.moalmanac.org",
    "last_updated": "2026-08-02"
  },
  "data": [
    {
      "id": "prop:vtxr:935",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:oncotree:ALL",
        "conceptType": "Disease",
        "name": "Acute Lymphoid Leukemia",
        "mappings": [],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": false,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
        "primaryCoding": {
          "id": "coding:oncotree:ALL",
          "code": "ALL",
          "name": "Acute Lymphoid Leukemia",
          "system": "https://oncotree.mskcc.org",
          "systemVersion": "oncotree_2021_11_02",
          "iris": [
            "https://oncotree.mskcc.org/?version=oncotree_2021_11_02&field=CODE&search=ALL"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "txgrp:206",
        "membershipOperator": "AND",
        "therapies": [
          {
            "id": "tx:ncit:C62091",
            "conceptType": "Therapy",
            "name": "Daunorubicin",
            "mappings": [
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:rxcui:3109",
                  "code": "3109",
                  "name": "daunorubicin",
                  "system": "RxNorm",
                  "systemVersion": "02-Mar-2026",
                  "iris": [
                    "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3109"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:1311799",
                  "code": "1311799",
                  "name": "daunorubicin",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/1311799"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:sctid:372715008",
                  "code": "372715008",
                  "name": "Daunorubicin",
                  "system": "SNOMED",
                  "systemVersion": "2025-03-01",
                  "iris": [
                    "https://browser.ihtsdotools.org/?perspective=full&conceptId1=372715008&edition=MAIN/2025-03-01&release=&languages=en"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:4156866",
                  "code": "4156866",
                  "name": "Daunorubicin",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/4156866"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
                  "Topoisomerase inhibition"
                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Chemotherapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C62091",
              "code": "C62091",
              "name": "Daunorubicin",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "25.01d",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C62091"
              ]
            }
          },
          {
            "id": "tx:ncit:C422",
            "conceptType": "Therapy",
            "name": "Dexamethasone",
            "mappings": [
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:rxcui:3264",
                  "code": "3264",
                  "name": "dexamethasone",
                  "system": "RxNorm",
                  "systemVersion": "02-Mar-2026",
                  "iris": [
                    "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=3264"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:1518254",
                  "code": "1518254",
                  "name": "dexamethasone",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/1518254"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:sctid:372584003",
                  "code": "372584003",
                  "name": "Dexamethasone",
                  "system": "SNOMED",
                  "systemVersion": "2025-03-01",
                  "iris": [
                    "https://browser.ihtsdotools.org/?perspective=full&conceptId1=372584003&edition=MAIN/2025-03-01&release=&languages=en"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:4156734",
                  "code": "4156734",
                  "name": "Dexamethasone",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/4156734"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
                  "Corticosteroid"
                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Chemotherapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C422",
              "code": "C422",
              "name": "Dexamethasone",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "25.01d",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C422"
              ]
            }
          },
          {
            "id": "tx:ncit:C62035",
            "conceptType": "Therapy",
            "name": "Imatinib",
            "mappings": [
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:rxcui:282388",
                  "code": "282388",
                  "name": "imatinib",
                  "system": "RxNorm",
                  "systemVersion": "20250602",
                  "iris": [
                    "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=282388"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:4185917",
                  "code": "4185917",
                  "name": "Imatinib",
                  "system": "OMOP",
                  "systemVersion": "v20250827",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/4185917"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:sctid:414460008",
                  "code": "414460008",
                  "name": "Imatinib",
                  "system": "SNOMED",
                  "systemVersion": "2026-03-01",
                  "iris": [
                    "https://browser.ihtsdotools.org/?perspective=full&conceptId1=414460008&edition=MAIN/2026-03-01&release=&languages=en"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:1304107",
                  "code": "1304107",
                  "name": "imatinib",
                  "system": "OMOP",
                  "systemVersion": "v20250827",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/1304107"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
                  "Bcr-Abl inhibition",
                  "c-Kit inhibition",
                  "PDGF-R inhibition"
                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Targeted therapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C62035",
              "code": "C62035",
              "name": "Imatinib",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "25.01d",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C62035"
              ]
            }
          },
          {
            "id": "tx:ncit:C642",
            "conceptType": "Therapy",
            "name": "Methotrexate",
            "mappings": [
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:rxcui:6851",
                  "code": "6851",
                  "name": "methotrexate",
                  "system": "RxNorm",
                  "systemVersion": "02-Mar-2026",
                  "iris": [
                    "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=6851"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:1305058",
                  "code": "1305058",
                  "name": "methotrexate",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/1305058"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:sctid:387381009",
                  "code": "387381009",
                  "name": "Methotrexate",
                  "system": "SNOMED",
                  "systemVersion": "2025-03-01",
                  "iris": [
                    "https://browser.ihtsdotools.org/?perspective=full&conceptId1=387381009&edition=MAIN/2025-03-01&release=&languages=en"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:4301206",
                  "code": "4301206",
                  "name": "Methotrexate",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/4301206"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
                  "Antifolate"
                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Chemotherapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C642",
              "code": "C642",
              "name": "Methotrexate",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "25.01d",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C642"
              ]
            }
          },
          {
            "id": "tx:ncit:C933",
            "conceptType": "Therapy",
            "name": "Vincristine",
            "mappings": [
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:rxcui:11202",
                  "code": "11202",
                  "name": "vincristine",
                  "system": "RxNorm",
                  "systemVersion": "02-Mar-2026",
                  "iris": [
                    "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=11202"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:1308290",
                  "code": "1308290",
                  "name": "vincristine",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/1308290"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:sctid:387126006",
                  "code": "387126006",
                  "name": "Vincristine",
                  "system": "SNOMED",
                  "systemVersion": "2025-03-01",
                  "iris": [
                    "https://browser.ihtsdotools.org/?perspective=full&conceptId1=387126006&edition=MAIN/2025-03-01&release=&languages=en"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:4304296",
                  "code": "4304296",
                  "name": "Vincristine",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/4304296"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
                  "Vinca alkaloid chemotherapy"
                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Chemotherapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C933",
              "code": "C933",
              "name": "Vincristine",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "25.01d",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C933"
              ]
            }
          }
        ]
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:12",
              "present": true,
              "subject": {
                "id": "bmkr:12",
                "type": "CategoricalVariant",
                "name": "BCR::ABL1",
                "constraints": [
                  {
                    "type": "AdjacencyConstraint",
                    "orderKnown": true,
                    "adjoinedElements": [
                      {
                        "id": "gene:hgnc:1014",
                        "conceptType": "Gene",
                        "name": "BCR",
                        "primaryCoding": {
                          "id": "coding:hgnc:1014",
                          "code": "HGNC:1014",
                          "system": "https://genenames.org",
                          "iris": [
                            "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1014"
                          ]
                        },
                        "mappings": [
                          {
                            "relation": "exactMatch",
                            "coding": {
                              "id": "coding:ensembl:ensg00000186716",
                              "code": "ENSG00000186716",
                              "system": "https://www.ensembl.org",
                              "iris": [
                                "https://www.ensembl.org/id/ENSG00000186716"
                              ]
                            }
                          },
                          {
                            "relation": "exactMatch",
                            "coding": {
                              "id": "coding:ncbi:613",
                              "code": "613",
                              "system": "https://www.ncbi.nlm.nih.gov/gene",
                              "iris": [
                                "https://www.ncbi.nlm.nih.gov/gene/613"
                              ]
                            }
                          },
                          {
                            "relation": "relatedMatch",
                            "coding": {
                              "id": "coding:refseq:NM_004327.4",
                              "code": "NM_004327.4",
                              "system": "https://www.ncbi.nlm.nih.gov/nuccore",
                              "iris": [
                                "https://www.ncbi.nlm.nih.gov/nuccore/NM_004327.4"
                              ]
                            }
                          }
                        ]
                      },
                      {
                        "id": "gene:hgnc:76",
                        "conceptType": "Gene",
                        "name": "ABL1",
                        "primaryCoding": {
                          "id": "coding:hgnc:76",
                          "code": "HGNC:76",
                          "system": "https://genenames.org",
                          "iris": [
                            "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:76"
                          ]
                        },
                        "mappings": [
                          {
                            "relation": "exactMatch",
                            "coding": {
                              "id": "coding:ensembl:ensg00000097007",
                              "code": "ENSG00000097007",
                              "system": "https://www.ensembl.org",
                              "iris": [
                                "https://www.ensembl.org/id/ENSG00000097007"
                              ]
                            }
                          },
                          {
                            "relation": "exactMatch",
                            "coding": {
                              "id": "coding:ncbi:25",
                              "code": "25",
                              "system": "https://www.ncbi.nlm.nih.gov/gene",
                              "iris": [
                                "https://www.ncbi.nlm.nih.gov/gene/25"
                              ]
                            }
                          },
                          {
                            "relation": "relatedMatch",
                            "coding": {
                              "id": "coding:refseq:NM_005157.6",
                              "code": "NM_005157.6",
                              "system": "https://www.ncbi.nlm.nih.gov/nuccore",
                              "iris": [
                                "https://www.ncbi.nlm.nih.gov/nuccore/NM_005157.6"
                              ]
                            }
                          }
                        ]
                      }
                    ]
                  }
                ],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Gene fusion"
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}