{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:951 retrieved successfully",
    "request_url": "https://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A951",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.002167,
    "timestamp_received": "2026-10-22T21:34:32.921427Z",
    "timestamp_returned": "2026-10-22T21:34:32.923594Z",
    "trace_id": "e9c7cb4c-b0f7-4e5c-9d60-94205fceaa3b"
  },
  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://moalmanac.org",
    "last_updated": "2026-10-08"
  },
  "data": [
    {
      "id": "prop:vtxr:951",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:ncit:C9245",
        "conceptType": "Disease",
        "name": "Invasive Breast Carcinoma",
        "mappings": [
          {
            "relation": "exactMatch",
            "coding": {
              "id": "coding:oncotree:BRCA",
              "code": "BRCA",
              "name": "Invasive Breast Carcinoma",
              "system": "https://oncotree.mskcc.org",
              "systemVersion": "oncotree_2025_10_03",
              "iris": [
                "https://oncotree.mskcc.org/?version=oncotree_2025_10_03&field=NAME&search=Invasive+Breast+Carcinoma+%28BRCA%29"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": true,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
        "primaryCoding": {
          "id": "coding:ncit:C9245",
          "code": "C9245",
          "name": "Invasive Breast Carcinoma",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "26.08e",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C9245"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "txgrp:63",
        "membershipOperator": "AND",
        "therapies": [
          {
            "id": "tx:ncit:C1411",
            "conceptType": "Therapy",
            "name": "Paclitaxel",
            "mappings": [
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:rxcui:56946",
                  "code": "56946",
                  "name": "paclitaxel",
                  "system": "RxNorm",
                  "systemVersion": "20250602",
                  "iris": [
                    "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=56946"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:1378382",
                  "code": "1378382",
                  "name": "paclitaxel",
                  "system": "OMOP",
                  "systemVersion": "v20250827",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/1378382"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
                  "Taxane-based chemotherapy"
                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Chemotherapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C1411",
              "code": "C1411",
              "name": "Paclitaxel",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "26.08e",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C1411"
              ]
            }
          },
          {
            "id": "tx:ncit:C106432",
            "conceptType": "Therapy",
            "name": "Pembrolizumab",
            "mappings": [
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:rxcui:1547545",
                  "code": "1547545",
                  "name": "pembrolizumab",
                  "system": "RxNorm",
                  "systemVersion": "02-Mar-2026",
                  "iris": [
                    "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1547545"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:45775965",
                  "code": "45775965",
                  "name": "pembrolizumab",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/45775965"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
                  "PD-1/PD-L1 inhibition"
                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Immunotherapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C106432",
              "code": "C106432",
              "name": "Pembrolizumab",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "26.08e",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C106432"
              ]
            }
          }
        ]
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:43",
              "present": true,
              "subject": {
                "id": "bmkr:43",
                "type": "CategoricalVariant",
                "name": "ER negative",
                "constraints": [],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Protein expression"
                  },
                  {
                    "name": "marker",
                    "value": "Estrogen receptor (ER)"
                  },
                  {
                    "name": "unit",
                    "value": "status"
                  },
                  {
                    "name": "equality",
                    "value": "="
                  },
                  {
                    "name": "value",
                    "value": "Negative"
                  }
                ]
              }
            },
            {
              "id": "bmkr.criterion:2",
              "present": true,
              "subject": {
                "id": "bmkr:2",
                "type": "CategoricalVariant",
                "name": "HER2-negative",
                "constraints": [],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Protein expression"
                  },
                  {
                    "name": "marker",
                    "value": "Human epidermal growth factor receptor 2 (HER2)"
                  },
                  {
                    "name": "unit",
                    "value": "status"
                  },
                  {
                    "name": "equality",
                    "value": "="
                  },
                  {
                    "name": "value",
                    "value": "Negative"
                  }
                ]
              }
            },
            {
              "id": "bmkr.criterion:41",
              "present": true,
              "subject": {
                "id": "bmkr:41",
                "type": "CategoricalVariant",
                "name": "PD-L1 (CPS) >= 10",
                "constraints": [],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Protein expression"
                  },
                  {
                    "name": "marker",
                    "value": "PD-L1"
                  },
                  {
                    "name": "unit",
                    "value": "Combined Positive Score (CPS)"
                  },
                  {
                    "name": "equality",
                    "value": ">="
                  },
                  {
                    "name": "value",
                    "value": 10
                  }
                ]
              }
            },
            {
              "id": "bmkr.criterion:190",
              "present": true,
              "subject": {
                "id": "bmkr:185",
                "type": "CategoricalVariant",
                "name": "PD-L1 < 1% IC",
                "constraints": [],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Protein expression"
                  },
                  {
                    "name": "marker",
                    "value": "PD-L1"
                  },
                  {
                    "name": "unit",
                    "value": "Immune cell staining (IC)"
                  },
                  {
                    "name": "equality",
                    "value": "<"
                  },
                  {
                    "name": "value",
                    "value": 0.01
                  }
                ]
              }
            },
            {
              "id": "bmkr.criterion:44",
              "present": true,
              "subject": {
                "id": "bmkr:44",
                "type": "CategoricalVariant",
                "name": "PR negative",
                "constraints": [],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Protein expression"
                  },
                  {
                    "name": "marker",
                    "value": "Progesterone receptor (PR)"
                  },
                  {
                    "name": "unit",
                    "value": "status"
                  },
                  {
                    "name": "equality",
                    "value": "="
                  },
                  {
                    "name": "value",
                    "value": "Negative"
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}