{
  "meta": {
    "data_length": 1,
    "message": "Proposition id prop:vtxr:985 retrieved successfully",
    "request_url": "https://api.moalmanac.org/propositions?proposition_id=prop%3Avtxr%3A985",
    "status": "success",
    "status_code": 200,
    "timestamp_elapsed": 0.001993,
    "timestamp_received": "2026-10-22T20:08:47.728765Z",
    "timestamp_returned": "2026-10-22T20:08:47.730758Z",
    "trace_id": "941dc84e-7a28-48b5-89e4-5e1ac5198356"
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  "service": {
    "github": "https://github.com/vanallenlab/moalmanac-db",
    "name": "Molecular Oncology Almanac",
    "license": "GPL-2.0",
    "release": "draft",
    "url": "https://moalmanac.org",
    "last_updated": "2026-10-08"
  },
  "data": [
    {
      "id": "prop:vtxr:985",
      "type": "VariantTherapeuticResponseProposition",
      "predicate": "predictsSensitivityTo",
      "subjectVariant": {
        "type": "CategoricalVariant",
        "description": "Placeholder. Cat-VRS does not yet support sets of categorical variants. See the 'biomarkers' extension for biomarkers associated with this Proposition."
      },
      "conditionQualifier": {
        "id": "dis:ncit:C2919",
        "conceptType": "Disease",
        "name": "Prostate Adenocarcinoma",
        "mappings": [
          {
            "relation": "exactMatch",
            "coding": {
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              "code": "PRAD",
              "name": "Prostate Adenocarcinoma",
              "system": "https://oncotree.mskcc.org",
              "systemVersion": "oncotree_2025_10_03",
              "iris": [
                "https://oncotree.mskcc.org/?version=oncotree_2025_10_03&field=NAME&search=Prostate+Adenocarcinoma+%28PRAD%29"
              ]
            }
          }
        ],
        "extensions": [
          {
            "name": "solid_tumor",
            "value": true,
            "description": "Boolean value for if this tumor type is categorized as a solid tumor."
          }
        ],
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          "code": "C2919",
          "name": "Prostate Adenocarcinoma",
          "system": "https://evsexplore.semantics.cancer.gov",
          "systemVersion": "26.08e",
          "iris": [
            "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C2919"
          ]
        }
      },
      "objectTherapeutic": {
        "id": "txgrp:224",
        "membershipOperator": "AND",
        "therapies": [
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            "id": "tx:ncit:C102564",
            "conceptType": "Therapy",
            "name": "Capivasertib",
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                "relation": "relatedMatch",
                "coding": {
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                  "systemVersion": "02-Mar-2026",
                  "iris": [
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                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
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                  "code": "747200",
                  "name": "capivasertib",
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                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/747200"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
                  "PI3K/AKT/mTOR inhibition"
                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Targeted therapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
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              "id": "coding:ncit:C102564",
              "code": "C102564",
              "name": "Capivasertib",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "26.08e",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C102564"
              ]
            }
          },
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            "id": "tx:ncit:C68845",
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            "name": "Abiraterone acetate",
            "mappings": [
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:rxcui:1100071",
                  "code": "1100071",
                  "name": "abiraterone acetate",
                  "system": "RxNorm",
                  "systemVersion": "20250602",
                  "iris": [
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                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:46274231",
                  "code": "46274231",
                  "name": "abiraterone acetate",
                  "system": "OMOP",
                  "systemVersion": "v20250827",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/46274231"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
                  "Antiandrogen"
                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Hormone therapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C68845",
              "code": "C68845",
              "name": "Abiraterone Acetate",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "26.08e",
              "iris": [
                "https://evsexplore.semantics.cancer.gov/evsexplore/concept/ncit/C68845"
              ]
            }
          },
          {
            "id": "tx:ncit:C770",
            "conceptType": "Therapy",
            "name": "Prednisone",
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              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:rxcui:8640",
                  "code": "8640",
                  "name": "prednisone",
                  "system": "RxNorm",
                  "systemVersion": "02-Mar-2026",
                  "iris": [
                    "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=8640"
                  ]
                }
              },
              {
                "relation": "relatedMatch",
                "coding": {
                  "id": "coding:omop:1551099",
                  "code": "1551099",
                  "name": "prednisone",
                  "system": "OMOP",
                  "systemVersion": "v20260227",
                  "iris": [
                    "https://athena.ohdsi.org/search-terms/terms/1551099"
                  ]
                }
              }
            ],
            "extensions": [
              {
                "name": "therapy_strategy",
                "value": [
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                ],
                "description": "Associated therapeutic strategy or mechanism of action of the therapy."
              },
              {
                "name": "therapy_type",
                "value": "Chemotherapy",
                "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
              }
            ],
            "primaryCoding": {
              "id": "coding:ncit:C770",
              "code": "C770",
              "name": "Prednisone",
              "system": "https://evsexplore.semantics.cancer.gov",
              "systemVersion": "26.08e",
              "iris": [
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              ]
            }
          }
        ]
      },
      "extensions": [
        {
          "name": "biomarkers",
          "value": [
            {
              "id": "bmkr.criterion:191",
              "present": true,
              "subject": {
                "id": "bmkr:186",
                "type": "CategoricalVariant",
                "name": "PTEN-deficient",
                "constraints": [],
                "extensions": [
                  {
                    "name": "biomarker_type",
                    "value": "Protein expression"
                  },
                  {
                    "name": "marker",
                    "value": "PTEN"
                  },
                  {
                    "name": "unit",
                    "value": "status"
                  },
                  {
                    "name": "equality",
                    "value": "="
                  },
                  {
                    "name": "value",
                    "value": "Deficient"
                  }
                ]
              }
            }
          ],
          "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
        }
      ]
    }
  ]
}