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      "type": "Statement",
      "description": "The Republic of Ireland's Health Service Executive (HSE) has approved alectinib for reimbursement as a monotherapy treatment option for the first-line treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC). This indication is specifically for patients whose tumors have been historically confirmed to be NSCLC with an ALK rearrangement identified by an approved and validated test method.",
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          ],
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            },
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              "relation": "relatedMatch",
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              "description": "Type of cancer treatment from cancer.gov: https://www.cancer.gov/about-cancer/treatment/types"
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          ],
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            "systemVersion": "26.08e",
            "iris": [
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          }
        },
        "extensions": [
          {
            "name": "biomarkers",
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              {
                "id": "bmkr.criterion:8",
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                    {
                      "type": "AdjacencyConstraint",
                      "orderKnown": false,
                      "adjoinedElements": [
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                                "code": "238",
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                                "iris": [
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                                "id": "coding:refseq:NM_004304.5",
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                  "extensions": [
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                      "name": "biomarker_type",
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                    }
                  ]
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              }
            ],
            "description": "The biomarkers associated with this Proposition, each with a `present` flag indicating if the biomarker is present (true) or absent (false). Multiple biomarkers are combined with implied AND logic."
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        ]
      },
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        "id": "str:ncit:C25425",
        "conceptType": "Evidence",
        "name": "Approval",
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          "id": "coding:ncit:C25425",
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          "systemVersion": "26.08e",
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          "value": "Active",
          "description": "Whether this Statement is Active, Superseded, or Deprecated within moalmanac-db."
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            "description": "As monotherapy is indicated for the first-line treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC).",
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                "name": "Alectinib Monotherapy. NCCP National SACT Regimen. HSE.",
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                "description": "Alectinib Monotherapy, 2025, version number 6, NCCP National SACT Regimen, NCCP, viewed 26/03/2026, https://healthservice.hse.ie/documents/6910/401_V6_Alectinib.pdf",
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          "description": "The underlying Indication supporting this Statement."
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}